The compelling medical drama “Doc” returns for its highly anticipated second season, premiering on FOX with next-day streaming on Hulu on September 14, 2025. The season continues the gripping story of Dr. Amy Larsen, a brilliant physician whose life was irrevocably altered by a devastating car accident that robbed her of her memory. Forced to navigate a world that is both familiar and utterly foreign, Amy must return to the hospital not as an experienced attending, but as an intern, relearning the complex medical skills she once mastered while trying to piece together the fragments of the personal life she left behind.

Leading the exceptional ensemble is the profoundly talented Molly Parker in the central role of Dr. Amy Larsen. She is joined by returning series regulars Omar Metwally, Jon-Michael Ecker, and Amirah Vann, who all reprise their roles as the colleagues, friends, and family who now relate to Amy as a stranger. Season 2 promises to delve deeper into the emotional and professional challenges of Amy’s unique situation, exploring themes of identity, resilience, and the possibility of building a new future when the past is a blank slate.

Doc Season 2 cast and crew 2025

1- Molly Parker as Dr. Amy Larsen

The immensely gifted Molly Parker returns to anchor the series in the demanding and nuanced role of Dr. Amy Larsen. Parker, an Emmy-nominated actress celebrated for her work in Deadwood, House of Cards, and Lost in Space, delivers a tour-de-force performance as a woman stripped of her identity. Her portrayal masterfully captures the profound disorientation, vulnerability, and fierce intelligence of a brilliant doctor trapped in the mind of a beginner, forced to rely on instinct and raw skill she cannot remember learning.

Parker’s performance is the heart and soul of “Doc,” as she navigates the dual challenge of relearning complex medical procedures while confronting the emotional minefield of her former relationships. She must rebuild connections with her husband, her daughter, and her colleagues from scratch, all while battling the underlying fear of what her past self might have been like. Parker brings a breathtaking depth to Amy’s journey, making her struggle for rediscovery both heartbreaking and inspiring.

2- Omar Metwally as Dr. Michael Hamda

Omar Metwally reprises his pivotal role as Dr. Michael Hamda, Amy’s husband and a fellow physician at the hospital. Metwally, a versatile actor known for his roles in Mr. Robot, The Affair, and the film Munich, brings a powerful emotional gravity to the series. Michael is trapped in an impossible situation: he is a stranger to the woman he loves, forced to balance his role as a supportive doctor guiding a new intern with his personal anguish and longing for his wife to remember their life together.

Metwally’s portrayal is a nuanced exploration of patience, grief, and unwavering love. He embodies the quiet agony of a man who must suppress his own heartbreak to provide the stable, understanding environment Amy needs to heal. His character’s journey is central to the show’s emotional core, as he desperately hopes that the woman he fell in love with is still in there somewhere, even if she can’t remember him.

3- Jon-Michael Ecker as Dr. Jake Heller

Jon-Michael Ecker returns as the charismatic and skilled Dr. Jake Heller. Ecker, known for his leading roles in Firefly Lane and Queen of the South, brings a compelling energy to the surgical wing. As a colleague and likely a friend from Amy’s past, Jake now finds himself in the bizarre position of being her superior and teacher. His character provides a unique perspective on the new Amy, potentially seeing a side of her that was buried before the accident.

Ecker’s performance adds layers of professional tension and potential romantic complication to the narrative. Jake represents the workplace dynamic that Amy must decipher, a world of hierarchies and unspoken histories that she is now on the bottom of. His interactions with Amy are filled with a fascinating mix of professional respect, personal curiosity, and the lingering ghost of a previous relationship that only he remembers.

4- Amirah Vann as Dr. Gina Walker

The superb Amirah Vann reprises her role as the sharp and capable Dr. Gina Walker. Vann, acclaimed for her performances in How to Get Away with Murder and Underground, brings authority and warmth to the hospital setting. As a fellow attending physician, Gina likely served as a close friend and confidante to the original Amy. Now, she must navigate a completely different relationship, acting as a mentor to a intern who possesses the mind of her peer.

Vann’s Dr. Walker is a pillar of strength and professionalism, representing the life Amy once had. Her character offers a crucial link to the past, and her reactions to the new Amy—perhaps frustration, empathy, or a determination to help her friend resurface—add rich texture to the medical drama. Gina stands as a reminder of the accomplished surgeon Amy was and, potentially, could be again.

5- Anya Banerjee as Dr. Sonya Maitra

Anya Banerjee returns as Dr. Sonya Maitra, a resident who now finds herself in a position of seniority over her former attending. Banerjee’s character provides a fascinating inversion of the typical hospital hierarchy. Dr. Maitra must balance the awkwardness of giving orders to her one-time boss with the professional responsibility to ensure patient safety and proper training.

Banerjee’s performance captures the complexity of this reversed dynamic, showcasing Sonya’s growth as a doctor since Amy’s accident. She represents the new generation of physicians who have had to step up in Amy’s absence, and her interactions with the intern version of Amy are filled with a unique blend of deference, pity, and newfound confidence.

6- Scott Wolf as Dr. Richard Miller

Scott Wolf joins the cast as Dr. Richard Miller. Wolf, a veteran actor known for his roles in Party of Five, The Night Shift, and Nancy Drew, brings a recognizable and steady presence to the hospital administration. As the Chief of Surgery or a senior department head, Dr. Miller is the man responsible for the impossible decision to allow Amy to retrain as an intern, balancing immense risk with a profound belief in her inherent talent.

Wolf’s character embodies the institutional and ethical dilemmas at play. Dr. Miller is tasked with overseeing Amy’s progress, protecting the hospital from liability, and managing the reactions of the staff. He represents the practical, often cold, realities of the situation that exist alongside the personal dramas, adding a layer of bureaucratic tension to the series.

7- Charlotte Fountain-Jardim as Katie / Katie Hamda

Charlotte Fountain-Jardim portrays Katie, also known as Katie Hamda, the daughter of Amy and Michael. Her role is one of the most emotionally charged in the series. One day her mother was a constant presence in her life, and the next, she was a kind but complete stranger. Fountain-Jardim must convey the profound confusion, sadness, and resilience of a young girl trying to understand why her mother doesn’t know her.

Her performance provides the most poignant stakes for Amy’s recovery. Every interaction between Katie and the new Amy is layered with a deep, unspoken history that only one of them remembers. Katie’s journey is about learning to love a new version of her mother while grieving the loss of the old one, a central emotional conflict that drives the heart of the show.

8- Patrick Walker as Dr. TJ Coleman

Patrick Walker joins the medical team as Dr. TJ Coleman, a fellow intern who is starting his career at the same time as the amnesiac Amy. Walker’s character offers a ground-level perspective, serving as Amy’s peer and potential friend in the grueling world of internships. Unlike everyone else, TJ has no preconceived notions of who Amy was; he only knows the person she is now.

Walker’s performance introduces a character free from the baggage of Amy’s past. TJ can be a source of camaraderie, normalcy, and honest feedback for Amy as they navigate the challenges of their new roles together. His presence allows for moments of levity and a relatable entry point into the intense training environment.

9- Claire Armstrong as Nurse Julie

Claire Armstrong returns as Nurse Julie, a seasoned nursing professional who has worked with Amy for years. Armstrong’s character represents the essential nursing staff who are the backbone of any hospital. Nurse Julie has a deep well of respect for the doctor Amy was and now must adapt to working with the intern she has become.

Armstrong’s performance highlights the crucial collaborative relationship between doctors and nurses. Nurse Julie can act as a subtle guide for Amy, offering help without condescension and perhaps providing small, crucial clues about Amy’s past self and how she operated in the hospital, serving as a friendly and familiar anchor in a confusing world.

10- Paulyne Wei as Nurse Lucy Yen

Paulyne Wei portrays Nurse Lucy Yen, another key member of the hospital’s nursing staff. Wei’s character brings her own expertise and perspective to the patient care team. As someone who likely had a professional relationship with the old Dr. Larsen, Nurse Yen now adjusts to a new dynamic, collaborating with a beginner who possesses a surprising, often inexplicable, intuition.

Wei’s performance contributes to the rich ecosystem of the hospital floor. Nurse Yen’s interactions with Amy add to the show’s authenticity, showcasing the daily teamwork required in medicine and how that dynamic is uniquely complicated when one team member is relearning everything from the ground up.

11- Conni Miu as Nurse Liz

Conni Miu rounds out the core cast as Nurse Liz. Miu’s character completes the portrayal of the nursing team that supports the doctors. Nurse Liz, like her colleagues, must navigate the unusual circumstance of having a former attending physician as a new intern. Her reactions—whether they are of kindness, curiosity, or professional caution—add another layer of realism to the hospital setting.

Miu’s presence ensures that the world of “Doc” feels fully populated and functional. The nurses provide a chorus of sorts, observing the central drama unfold and responding to the new Dr. Larsen from their unique and essential vantage point, grounding the high-concept premise in the day-to-day reality of hospital life.