The award-winning daytime talk show that feels like a breath of fresh air returns for its sixth season! The Drew Barrymore Show continues to redefine the genre with its unique blend of heartfelt conversations, uplifting human-interest stories, and laugh-out-loud moments, all guided by the inimitable Drew Barrymore. Driven by her infectious humor, genuine curiosity, and unwavering optimism, each episode is a celebration of the human spirit, designed to entertain, inspire, and make viewers feel seen and understood. From A-list celebrity interviews to transformative lifestyle segments and hilarious field pieces, the show is a daily dose of joy and connection.

Season 6 promises to be the most dynamic yet, with new segments, surprise guests, and even more audience interaction. Drew’s unique ability to create an instant rapport with everyone from Hollywood icons to everyday heroes remains the show’s cornerstone, turning interviews into authentic conversations and studio moments into shared experiences. Whether she’s dishing on the latest trends, tackling life’s challenges with expert advice, or simply sharing a vulnerable personal story, Drew’s mission is clear: to spread kindness, foster community, and remind us all to find the light in every day.

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The Drew Barrymore Show Season 6 main cast

1: Drew Barrymore as Self – Host

Drew Barrymore is the heart, soul, and radiant energy of the show, bringing her legendary warmth, vulnerability, and comedic timing to every segment. As the host, she effortlessly transitions from deep, empathetic interviews to playful comedy bits, creating a welcoming atmosphere that makes guests and viewers feel like old friends. Her infectious enthusiasm and genuine passion for storytelling are the driving forces behind the show’s success, turning each episode into a memorable experience.

Drew’s unique perspective, shaped by her decades in the spotlight and her personal journey of growth, allows her to connect with people on a profound level. Whether she’s sharing a personal anecdote, dancing with a guest, or tearing up during a moving human-interest story, her authenticity is undeniable. She doesn’t just host the show; she curates a daily celebration of life’s beautiful messiness, inspiring audiences to embrace their own stories with courage and joy.

2: Ross Mathews as Self – Drew’s News Contributor

Ross Mathews returns as the show’s beloved news contributor, delivering his signature blend of hilarious commentary and pop culture expertise. With his quick wit and boundless charm, Ross breaks down the day’s biggest headlines, trending topics, and viral moments, always adding a dose of levity and heart. His segments are a fan favorite, offering a joyful escape into the world of entertainment with his unique, relatable perspective.

Ross’s chemistry with Drew is electric, often leading to spontaneous moments of comedy and genuine connection. His ability to find humor in everyday life while maintaining a deep empathy for the stories he covers makes him the perfect co-pilot for Drew’s daily journey. He is the show’s cheerleader, confidant, and resident funnyman, keeping the energy high and the laughs coming.

3: Pilar Valdes as Self – Guest

Pilar Valdes brings her vibrant energy and creative flair as a recurring guest, often joining Drew for design and lifestyle segments. Known for her work on Queer Eye, Pilar excels at offering practical, stylish tips for transforming spaces and lives. Her expertise in organization and home aesthetics provides viewers with actionable advice to create environments that spark joy and reflect their personalities.

Pilar’s warm and approachable demeanor makes her segments both informative and deeply relatable. Whether she’s helping a viewer redesign a room or sharing her favorite budget-friendly hacks, her passion for empowering others shines through. Her collaboration with Drew is filled with mutual admiration and fun, making every segment a delightful masterclass in living beautifully.

4: Mikel Welch as Self – Guest

Mikel Welch is a standout guest, lending his impeccable taste and design expertise to the show’s lifestyle segments. As an acclaimed interior designer and television personality, Mikel specializes in creating elegant, functional spaces that tell a story. His segments often focus on seasonal decor, entertaining tips, and how to infuse personality into every corner of your home.

Mikel’s charismatic presence and eye for detail make his segments a visual treat. His easygoing rapport with Drew allows for engaging conversations about design, trends, and the emotional connections we have with our spaces. He embodies the show’s mission to inspire creativity and help viewers build homes that feel like sanctuaries.

5: Valerie Bertinelli as Self – Lifestyle Expert

Valerie Bertinelli joins the show as a lifestyle expert, sharing her wealth of knowledge on food, wellness, and living with intention. As a beloved actress and bestselling author, Valerie brings a down-to-earth warmth to her segments, whether she’s whipping up a comforting recipe or discussing strategies for finding balance and joy in daily life.

Valerie’s authenticity and relatable journey resonate deeply with viewers. Her conversations with Drew often feel like catching up with a wise friend, filled with laughter, honesty, and practical wisdom. From kitchen tips to heartfelt discussions about self-care, Valerie’s contributions enrich the show’s focus on nurturing mind, body, and spirit.

6: Danny Seo as Self – Guest

Danny Seo is a recurring guest, celebrated for his innovative ideas on sustainable living and eco-friendly design. As a lifestyle expert and environmentalist, Danny shares tips on how to live beautifully while minimizing your carbon footprint. His segments are packed with creative DIY projects, upcycling ideas, and strategies for incorporating sustainability into everyday routines.

Danny’s passion for the planet is infectious, and his practical advice makes eco-conscious living accessible to everyone. His dynamic with Drew is filled with curiosity and collaboration, as they explore ways to merge style with sustainability. Danny’s segments empower viewers to make small changes that have a big impact, aligning perfectly with the show’s uplifting message.

7: Zanna Roberts Rassi as Self – Guest

Zanna Roberts Rassi brings her fashion expertise to the show as a guest contributor, offering insights into the latest trends, red carpet looks, and styling tips. As a renowned fashion journalist and designer, Zanna has an eye for what’s next in the world of style, making her segments a must-watch for fashion enthusiasts.

Zanna’s segments are chic, informative, and endlessly fun, often featuring try-ons, celebrity style breakdowns, and accessible tips for elevating everyday outfits. Her chemistry with Drew is palpable, as they bond over their love of fashion and self-expression. Zanna’s contributions ensure that the show remains a destination for style inspiration and confidence-building.

8: Eitan Bernath as Self – Guest

Eitan Bernath is a dynamic guest, known for his culinary skills and Gen Z perspective on food and culture. As a chef, author, and social media sensation, Eitan brings energy and innovation to the show’s cooking segments, whipping up delicious recipes that are both approachable and exciting.

Eitan’s youthful exuberance and talent in the kitchen make his segments a blast to watch. Whether he’s teaching Drew how to master a trending dish or sharing his favorite comfort food hacks, his passion for cooking is contagious. His presence adds a fresh, modern twist to the show’s lifestyle content, appealing to food lovers of all ages.

9: Chris Appleton as Self – Celebrity Stylist

Chris Appleton joins as a celebrity stylist, offering glamorous transformations and expert beauty advice. Known for his work with A-list stars, Chris brings his artistry to the show, demonstrating cutting-edge hairstyling techniques, makeup trends, and tips for achieving red-carpet-ready looks at home.

Chris’s segments are equal parts education and entertainment, filled with stunning makeovers and behind-the-scenes insights into the world of celebrity styling. His charismatic personality and creative genius make him a natural fit for the show, and his collaborations with Drew are always filled with laughter and stunning results.

10: Damona Hoffman as Self – Dating Expert

Damona Hoffman provides valuable insights as the show’s dating expert, helping viewers navigate the complexities of modern relationships. As a certified dating coach and podcast host, Damona offers practical advice on everything from first dates to long-term commitment, always with a blend of humor and empathy.

Damona’s segments are engaging and relatable, often featuring audience questions and interactive exercises. Her expertise helps demystify the dating world, empowering viewers to build meaningful connections. Her conversations with Drew are candid and supportive, reflecting the show’s commitment to tackling real-life topics with heart and intelligence.

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Why Season 6 Will Be the Best Yet

• More Celebrity Magic: Intimate and unforgettable interviews with the biggest names in entertainment.

• Inspiring Stories: Heartwarming human-interest segments that highlight resilience and kindness.

• Practical Tips: From home design to self-care, expert advice to enhance your daily life.

• Drew’s Signature Sparkle: Unscripted moments of joy, humor, and authenticity that only Drew can deliver.

Tune In for Your Daily Dose of Happy

The Drew Barrymore Show Season 6 premieres September 8, 2025, on CBS. Don’t miss a moment of the fun, laughter, and inspiration.